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What is erythromycin?

Erythromycin treats infections and can help with stomach emptying. It is available in multiple forms including capsules, tablets (some extended-release), liquid suspensions, IV solutions, eye ointment, and topical preparations.

Erythromycin at home

  • Follow food instructions for the prescribed brand (some require empty stomach).
  • Shake oral liquids well and measure with the supplied device.
  • Most liquids require refrigeration; check with the pharmacist.
  • Discard liquids and eye ointment after the labeled expiration date.
  • Store tablets and capsules at room temperature in a dry place.
  • Swallow extended-release tablets/capsules whole.

Possible side effects

  • Nausea and vomiting
  • Diarrhea
  • Rash
  • Loss of appetite
  • Headache
  • Stomach pain
  • Indigestion
  • Ringing in the ears or hearing loss (especially with IV)
  • Pain at IV site
  • Abnormal liver function (yellowing skin/eyes, dark urine)
  • Symptoms of allergic reaction include rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck
  • Not all patients will experience these side effects. Report any symptoms to the care team.

Tips for patients and families

  • Discuss all questions with your doctor or pharmacist.
  • Inform the care team about any prior allergic reaction to erythromycin.
  • Report signs of liver issues or severe diarrhea immediately.
  • Finish all doses as prescribed; do not stop early without medical advice.
  • Be aware of drug interactions (warfarin, theophylline, cyclosporine, phenytoin, carbamazepine, ranitidine, omeprazole, triazolam, astemizole, ergotamine, ritonavir, zidovudine, fluconazole, valproic acid, estrogen-containing birth control, digoxin).
  • Use additional birth control for 1 month after therapy if taking estrogen-based contraceptives.