Often used for:
Leukemia, lymphoma
About pegaspargase
Pegaspargase is a PEGylated form of asparaginase that slows or stops cancer cell growth and is often used in combination regimens. Patients are closely monitored for allergic reactions and receive regular labs for blood counts, clotting factors, pancreatic enzymes, glucose, and organ function.
Possible side effects
- Increased blood sugar
- Increased risk of bleeding or blood clots
- Liver problems
- High triglyceride levels
- Nausea and vomiting
- Fever
- Abdominal pain or pancreatitis
- Increased risk of stroke
- Injection-site swelling, pain, or warmth
- Allergic reactions (hives, rash, itching, trouble breathing or swallowing)
- Not all patients experience these side effects. Report all symptoms promptly.
Tips for families
- Discuss all instructions with the doctor or pharmacist.
- Inform the care team of any history of pancreatitis, blood clots, or severe bleeding, especially with previous asparaginase therapy.
- Use reliable birth control during treatment and for 6 months after therapy.
- Tell the care team if pregnant or breastfeeding.
- Caregivers should follow safe handling and disposal instructions.
