Often used for:
Brain tumors and conditioning before hematopoietic cell transplant
About thiotepa
Thiotepa is a chemotherapy agent that may be given IV or intrathecally. It slows cancer cell growth and is often part of transplant conditioning regimens.
Possible long-term effects
- Fertility problems
- Second cancers
Possible side effects
- Nausea or vomiting
- Eye pain or irritation
- Temporary skin darkening
- Skin irritation at the IV site
- Low blood counts
- Loss of appetite and weight loss
- Dizziness
- Fatigue or weakness
- Headache
- Abdominal pain
- Mouth sores
- Hair loss
- Menstrual changes
- Infertility
- Liver problems
- Not all patients experience these effects. Report all symptoms.
Tips for families
- Discuss instructions with the care team.
- Avoid skin contact with thiotepa in sweat for 24 hours after administration; follow bathing and clothing change recommendations.
- Caregivers should wear gloves when handling contaminated items.
- Use birth control during treatment and for 6 months afterward.
- Inform the doctor if pregnant or breastfeeding.
- Follow safe handling procedures for body fluids for 48 hours after dosing.
